Transforming growth factor-β1 and diabetic nephropathy
نویسندگان
چکیده
منابع مشابه
Transforming growth factor-β1 and diabetic nephropathy.
Transforming growth factor-β1 (TGF-β1) is established to be involved in the pathogenesis of diabetic nephropathy. The diabetic milieu enhances oxidative stress and induces the expression of TGF-β1. TGF-β1 promotes cell hypertrophy and extracellular matrix accumulation in the mesangium, which decreases glomerular filtration rate and leads to chronic renal failure. Recently, TGF-β1 has been demon...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Renal Physiology
سال: 2016
ISSN: 1931-857X,1522-1466
DOI: 10.1152/ajprenal.00502.2015